Assay Detail
Binding
CHEMBL5226846
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Inhibition of DHCR7 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.23 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5281526 | — | — | 1 | 10.00 |
| CHEMBL5284923 | — | — | 1 | 7.52 |
| CHEMBL5285995 | — | — | 1 | 5.97 |
| CHEMBL4454956 | — | — | 1 | 5.86 |
| CHEMBL5270628 | — | — | 1 | 5.69 |
| CHEMBL5285729 | — | — | 1 | 4.30 |
| CHEMBL4544901 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5281526 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5284923 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5285995 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4454956 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5270628 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5285729 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4544901 | — | IC50 | = | 50000.0 | nM | 4.30 |