Assay Detail
Functional
CHEMBL5226853
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Anticancer activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by Cell Titer-Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34704 | — | — | 1 | 6.03 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.02 |
| CHEMBL2103875 | TRAMETINIB | 4.0 | 1 | 5.94 |
| CHEMBL5290294 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34704 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL2103875 | TRAMETINIB | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5290294 | — | IC50 | = | 1420.0 | nM | 5.85 |