Assay Detail
Functional
CHEMBL5226893
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.71 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179197 | — | — | 1 | 6.11 |
| CHEMBL5289727 | — | — | 1 | 5.92 |
| CHEMBL460433 | CALPHOSTIN C | — | 1 | 5.54 |
| CHEMBL578512 | — | — | 1 | 5.54 |
| CHEMBL5266763 | — | — | 1 | 5.44 |
| CHEMBL5282500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179197 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5289727 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL460433 | CALPHOSTIN C | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL578512 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL5266763 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5282500 | — | IC50 | < | 150.0 | nM | - |