Assay Detail
Functional
CHEMBL5226915
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Anticancer activity against human HCT-116 cells assessed as reduction in cell viability
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.29 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4248974 | — | — | 1 | 8.10 |
| CHEMBL5189621 | — | — | 1 | 6.24 |
| CHEMBL5267289 | — | — | 1 | 4.54 |
| CHEMBL5269132 | — | — | 1 | - |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
| CHEMBL5275711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4248974 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5189621 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5267289 | — | IC50 | = | 28830.0 | nM | 4.54 |
| CHEMBL5269132 | — | IC50 | = | 36.0 | ug.mL-1 | - |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | < | 50000.0 | nM | - |
| CHEMBL5275711 | — | IC50 | < | 50000.0 | nM | - |