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Assay Detail

CHEMBL5226936

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation.
Bai R, Yao C, Zhong Z, Ge J, Bai Z, Ye X, Xie T, Xie Y.
Eur J Med Chem (2021) 213 : 113165 -113165
PubMed 33454546 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.41 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5268602 1 6.10
CHEMBL5272335 1 5.89
CHEMBL5285663 1 5.86
CHEMBL5286897 1 5.86
CHEMBL483825 1 5.86
CHEMBL37736 LIRIODENINE 1 5.86
CHEMBL5280644 1 5.80
CHEMBL225304 PIMAGEDINE 2.0 1 5.75
CHEMBL5269896 1 5.62
CHEMBL389621 HYDROCORTISONE 4.0 1 5.47
CHEMBL5280020 1 5.44
CHEMBL5290068 1 5.11
CHEMBL507845 1 5.04
CHEMBL5290481 1 4.92
CHEMBL5275797 1 4.92
CHEMBL5286728 1 4.82
CHEMBL5271297 1 4.59
CHEMBL5287469 1 4.41
CHEMBL5278330 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5268602 IC50 = 800.0 nM 6.10
CHEMBL5272335 IC50 = 1300.0 nM 5.89
CHEMBL5285663 IC50 = 1390.0 nM 5.86
CHEMBL5286897 IC50 = 1390.0 nM 5.86
CHEMBL483825 IC50 = 1390.0 nM 5.86
CHEMBL37736 LIRIODENINE IC50 = 1390.0 nM 5.86
CHEMBL5280644 IC50 = 1600.0 nM 5.80
CHEMBL225304 PIMAGEDINE IC50 = 1800.0 nM 5.75
CHEMBL5269896 IC50 = 2400.0 nM 5.62
CHEMBL389621 HYDROCORTISONE IC50 = 3400.0 nM 5.47
CHEMBL5280020 IC50 = 3600.0 nM 5.44
CHEMBL5290068 IC50 = 7700.0 nM 5.11
CHEMBL507845 IC50 = 9100.0 nM 5.04
CHEMBL5290481 IC50 = 12000.0 nM 4.92
CHEMBL5275797 IC50 = 12000.0 nM 4.92
CHEMBL5286728 IC50 = 15100.0 nM 4.82
CHEMBL5271297 IC50 = 25500.0 nM 4.59
CHEMBL5287469 IC50 = 38600.0 nM 4.41
CHEMBL5278330 IC50 = 105100.0 nM -