Assay Detail
Functional
CHEMBL5226964
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Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated with compound for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.75 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018557 | — | — | 1 | 5.17 |
| CHEMBL458702 | DECARINE | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018557 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL458702 | DECARINE | IC50 | = | 48400.0 | nM | 4.32 |