Assay Detail
Binding
CHEMBL5227016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-COV2 main protease using Mca-AVLQ-SGFR-K as substrate by Fluorescence microplate reader assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.40 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5268979 | — | — | 1 | 6.17 |
| CHEMBL5280512 | — | — | 1 | 5.81 |
| CHEMBL460499 | CARMOFUR | 2.0 | 1 | 5.74 |
| CHEMBL284861 | — | — | 1 | 5.60 |
| CHEMBL964 | DISULFIRAM | 4.0 | 1 | 5.03 |
| CHEMBL9470 | SHIKONIN | — | 1 | 4.80 |
| CHEMBL406050 | PX-12 | 2.0 | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5268979 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5280512 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL460499 | CARMOFUR | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL284861 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL964 | DISULFIRAM | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 15750.0 | nM | 4.80 |
| CHEMBL406050 | PX-12 | IC50 | = | 21390.0 | nM | 4.67 |