Assay Detail
Binding
CHEMBL5227420
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Inhibition of CDK2/Cyclin A (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Fused-azepinones: Emerging scaffolds of medicinal importance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.46 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 7.82 |
| CHEMBL299756 | PAULLONE 2 | — | 1 | 7.62 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.16 |
| CHEMBL259638 | CAZPAULLONE | — | 1 | 6.30 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.17 |
| CHEMBL336961 | AZAKENPAULLONE | — | 1 | 5.70 |
| CHEMBL1782168 | — | — | 1 | 5.68 |
| CHEMBL1782169 | — | — | 1 | 5.21 |
| CHEMBL1782170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL299756 | PAULLONE 2 | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL259638 | CAZPAULLONE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL336961 | AZAKENPAULLONE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1782168 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1782169 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1782170 | — | IC50 | > | 10000.0 | nM | - |