Assay Detail
Binding
CHEMBL5227427
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Inhibition of rabbit muscle GSK3beta in presence of gamma32P-ATP
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fused-azepinones: Emerging scaffolds of medicinal importance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.77 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 8.40 |
| CHEMBL259638 | CAZPAULLONE | — | 1 | 8.10 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 8.00 |
| CHEMBL336961 | AZAKENPAULLONE | — | 1 | 7.75 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 7.64 |
| CHEMBL1233473 | — | — | 1 | 7.33 |
| CHEMBL5277152 | — | — | 1 | 7.33 |
| CHEMBL480350 | — | — | 1 | 7.29 |
| CHEMBL5281583 | — | — | 1 | 7.29 |
| CHEMBL5285766 | — | — | 1 | 7.28 |
| CHEMBL481333 | — | — | 1 | 7.19 |
| CHEMBL5272006 | — | — | 1 | 7.06 |
| CHEMBL5271328 | — | — | 1 | 7.05 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | — | 2 | 6.96 |
| CHEMBL5267995 | — | — | 1 | 6.44 |
| CHEMBL5265856 | — | — | 1 | 6.25 |
| CHEMBL5280645 | — | — | 1 | 6.21 |
| CHEMBL1782168 | — | — | 1 | 6.09 |
| CHEMBL5272265 | — | — | 1 | 5.86 |
| CHEMBL512682 | SPONGIACIDIN D | — | 1 | 5.52 |
| CHEMBL1782169 | — | — | 1 | 5.47 |
| CHEMBL323657 | — | — | 1 | 5.40 |
| CHEMBL5267075 | — | — | 1 | 5.37 |
| CHEMBL134501 | — | — | 1 | 4.92 |
| CHEMBL1782170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL259638 | CAZPAULLONE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL336961 | AZAKENPAULLONE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1233473 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5277152 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL480350 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5281583 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5285766 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL481333 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5272006 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5271328 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5267995 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL5265856 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL5280645 | — | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL1782168 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5272265 | — | IC50 | = | 1388.0 | nM | 5.86 |
| CHEMBL512682 | SPONGIACIDIN D | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1782169 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL323657 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5267075 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL134501 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1782170 | — | IC50 | > | 10000.0 | nM | - |