Compound Detail
CHEMBL512682
SPONGIACIDIN D Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL512682 |
| Name | SPONGIACIDIN D |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LEWMERXWKZWRBX-DAXSKMNVSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
325.1
MW (Da)
0.46
ALogP
3
HBA
4
HBD
103.1
PSA (Ų)
0.41
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
| Cyclin-dependent kinase 1/cyclin B CHEMBL2094127 | IC50 | 5.4 | 5.4 | 4000.0 | 1 |
| Casein kinase I CHEMBL2111458 | IC50 | 5.35 | 5.35 | 4500.0 | 1 |
| Cyclin-dependent kinase 5/CDK5 activator 1 CHEMBL1907600 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
| Protein kinase C (PKC) CHEMBL2093867 | IC50 | 5.05 | 5.05 | 9000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of rabbit muscle GSK3beta in presence of gamma32P-ATP | 33901899 |
| Cyclin-dependent kinase 1/cyclin B | IC50 | = | 4000.0 | nM | 5.4 | Inhibition of CDK1/Cyclin B (unknown origin) in presence of gamma32P-ATP by scin... | 33901899 |
| Casein kinase I | IC50 | = | 4500.0 | nM | 5.35 | Inhibition of CK1 (unknown origin) | 33901899 |
| Cyclin-dependent kinase 5/CDK5 activator 1 | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of CDK5/p25 (unknown origin) | 33901899 |
| Protein kinase C (PKC) | IC50 | = | 9000.0 | nM | 5.05 | Inhibition of Protein kinase C (unknown origin) | 33901899 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9599282 | 10.1021/np970565h | Receptor tyrosine-protein kinase erbB-2 | 1 |
| 9599282 | 10.1021/np970565h | Cyclin-dependent kinase 4 | 1 |
| 33901899 | 10.1016/j.ejmech.2021.113445 | Cyclin-dependent kinase 1/cyclin B | 1 |
| 33901899 | 10.1016/j.ejmech.2021.113445 | Protein kinase C (PKC) | 1 |
| 33901899 | 10.1016/j.ejmech.2021.113445 | Unchecked | 1 |
| 33901899 | 10.1016/j.ejmech.2021.113445 | Casein kinase I | 1 |
| 33901899 | 10.1016/j.ejmech.2021.113445 | Cyclin-dependent kinase 5/CDK5 activator 1 | 1 |
Data from ChEMBL 36 via Core Engine