Assay Detail
Binding
CHEMBL5227418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1/Cyclin B (unknown origin) in presence of gamma32P-ATP by scintillation counter analysis
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Fused-azepinones: Emerging scaffolds of medicinal importance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.22 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.66 |
| CHEMBL299756 | PAULLONE 2 | — | 1 | 7.62 |
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 7.46 |
| CHEMBL1233473 | — | — | 1 | 6.66 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | — | 2 | 6.60 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.40 |
| CHEMBL259638 | CAZPAULLONE | — | 1 | 6.30 |
| CHEMBL480350 | — | — | 1 | 6.28 |
| CHEMBL5285766 | — | — | 1 | 6.26 |
| CHEMBL323657 | — | — | 1 | 6.22 |
| CHEMBL481333 | — | — | 1 | 6.10 |
| CHEMBL5277152 | — | — | 1 | 6.00 |
| CHEMBL5267995 | — | — | 1 | 5.82 |
| CHEMBL5271328 | — | — | 1 | 5.82 |
| CHEMBL336961 | AZAKENPAULLONE | — | 1 | 5.70 |
| CHEMBL1782168 | — | — | 1 | 5.68 |
| CHEMBL5281583 | — | — | 1 | 5.64 |
| CHEMBL512682 | SPONGIACIDIN D | — | 1 | 5.40 |
| CHEMBL1782169 | — | — | 1 | 5.24 |
| CHEMBL134501 | — | — | 1 | 5.08 |
| CHEMBL5272265 | — | — | 1 | - |
| CHEMBL1782170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL299756 | PAULLONE 2 | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1233473 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL259638 | CAZPAULLONE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL480350 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5285766 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL323657 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL481333 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5277152 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5267995 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5271328 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL336961 | AZAKENPAULLONE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1782168 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5281583 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL512682 | SPONGIACIDIN D | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1782169 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL134501 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5272265 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1782170 | — | IC50 | > | 10000.0 | nM | - |