Assay Detail
Binding
CHEMBL5227431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK5/p25 (unknown origin)
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Fused-azepinones: Emerging scaffolds of medicinal importance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.50 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5265856 | — | — | 1 | 7.92 |
| CHEMBL5272006 | — | — | 1 | 7.92 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.60 |
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 7.40 |
| CHEMBL480350 | — | — | 1 | 7.25 |
| CHEMBL1233473 | — | — | 1 | 7.21 |
| CHEMBL5280645 | — | — | 1 | 7.12 |
| CHEMBL5271328 | — | — | 1 | 7.10 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | — | 2 | 6.95 |
| CHEMBL323657 | — | — | 1 | 6.92 |
| CHEMBL5285766 | — | — | 1 | 6.75 |
| CHEMBL481333 | — | — | 1 | 6.75 |
| CHEMBL5281583 | — | — | 1 | 6.72 |
| CHEMBL5277152 | — | — | 1 | 6.67 |
| CHEMBL259638 | CAZPAULLONE | — | 1 | 6.52 |
| CHEMBL5267995 | — | — | 1 | 6.27 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.07 |
| CHEMBL1782168 | — | — | 1 | 5.52 |
| CHEMBL336961 | AZAKENPAULLONE | — | 1 | 5.38 |
| CHEMBL134501 | — | — | 1 | 5.22 |
| CHEMBL512682 | SPONGIACIDIN D | — | 1 | 5.16 |
| CHEMBL1782169 | — | — | 1 | 5.14 |
| CHEMBL5272265 | — | — | 1 | 5.04 |
| CHEMBL5267075 | — | — | 1 | 4.98 |
| CHEMBL1782170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5265856 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5272006 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL480350 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1233473 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5280645 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5271328 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL323657 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5285766 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL481333 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5281583 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL5277152 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL259638 | CAZPAULLONE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5267995 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1782168 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL336961 | AZAKENPAULLONE | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL134501 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL512682 | SPONGIACIDIN D | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1782169 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5272265 | — | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL5267075 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1782170 | — | IC50 | > | 10000.0 | nM | - |