Assay Detail

CHEMBL5227475

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Binding

Inhibition of GSK3alpha (unknown origin)

ChEMBL ↗

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Target

Glycogen synthase kinase-3 alpha (CHEMBL2850) ↗

Open DB target context

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Glycogen synthase kinase-3 alpha (CHEMBL2850) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Glycogen synthase kinase-3 alpha

CHEMBL2850

Anchored from Assay target.

Protein identity Glycogen synthase kinase-3 alpha

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Glycogen synthase kinase-3 alpha (CHEMBL2850) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Fused-azepinones: Emerging scaffolds of medicinal importance.

Akunuri R, Vadakattu M, Bujji S, Veerareddy V, Madhavi YV, Nanduri S.
Eur J Med Chem (2021) 220 : 113445 -113445
PubMed 33901899 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL50894	ALSTERPAULLONE	—	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL50894	ALSTERPAULLONE	IC50	=	4.0	nM	8.40