Assay Detail
Binding
CHEMBL5227561
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Inhibition of PDE10A (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL4409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.99 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5281567 | — | — | 1 | 10.22 |
| CHEMBL5268340 | — | — | 1 | 9.89 |
| CHEMBL3319209 | — | — | 1 | 9.74 |
| CHEMBL1915747 | — | — | 1 | 9.30 |
| CHEMBL5272386 | — | — | 1 | 9.11 |
| CHEMBL5288053 | — | — | 1 | 8.72 |
| CHEMBL1915749 | — | — | 1 | 8.70 |
| CHEMBL219445 | — | — | 1 | 7.80 |
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5281567 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL5268340 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3319209 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL1915747 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5272386 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL5288053 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1915749 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL219445 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL19224 | PAPAVERINE | IC50 | = | 36.0 | nM | 7.44 |