Compound Detail
CHEMBL5288053
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Basic Information
| ChEMBL ID | CHEMBL5288053 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CDCZTLPFRMEYFM-NUTRPMROSA-N |
| Parent Compound | CHEMBL1956235 |
| Active Moiety | CHEMBL1956235 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
338.4
MW (Da)
3.84
ALogP
6
HBA
1
HBD
69.2
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL4409 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | IC50 | = | 1.9 | nM | 8.72 | Inhibition of PDE10A (unknown origin) | 34042442 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34042442 | 10.1021/acs.jmedchem.1c00115 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 1 |
Data from ChEMBL 36 via Core Engine