Assay Detail
Binding
CHEMBL5227900
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Binding affinity to STAT3 (unknown origin) by SPR analysis
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.15 | 6.30 |
| IC50 | 2 | 5.78 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829876 | — | — | 1 | 6.30 |
| CHEMBL5280147 | — | — | 1 | 6.16 |
| CHEMBL3392776 | C-188-9 | 2.0 | 1 | 5.40 |
| CHEMBL5282950 | — | — | 1 | 4.81 |
| CHEMBL5268863 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829876 | — | Kd | = | 504.0 | nM | 6.30 |
| CHEMBL5280147 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3392776 | C-188-9 | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5282950 | — | Kd | = | 15500.0 | nM | 4.81 |
| CHEMBL5268863 | — | Kd | = | 45000.0 | nM | 4.35 |