Assay Detail
Binding
CHEMBL5227901
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Inhibition of STAT3 (unknown origin) DNA binding activity by EMSA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.30 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3108909 | — | — | 1 | 5.41 |
| CHEMBL3108910 | — | — | 1 | 5.33 |
| CHEMBL1829876 | — | — | 1 | 5.17 |
| CHEMBL5270588 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3108909 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3108910 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1829876 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5270588 | — | IC50 | = | 0.0024 | nM | - |