Assay Detail
Binding
CHEMBL5227966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-6 (CHEMBL2163182) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Emerging Therapeutic Potential of SIRT6 Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.67 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280065 | OLEOYLETHANOLAMIDE | — | 1 | 5.51 |
| CHEMBL5277451 | — | — | 1 | 5.12 |
| CHEMBL8659 | OLEIC ACID | 2.0 | 1 | 4.05 |
| CHEMBL267476 | LINOLEIC ACID | 2.0 | 1 | 4.00 |
| CHEMBL111077 | MYRISTIC ACID | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280065 | OLEOYLETHANOLAMIDE | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5277451 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL8659 | OLEIC ACID | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL267476 | LINOLEIC ACID | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL111077 | MYRISTIC ACID | EC50 | = | 246000.0 | nM | - |