Assay Detail
Binding
CHEMBL5228263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CB34 from TSPO receptor in rat brain cortex membrane by liquid scintillation spectrometer method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.07 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325820 | — | — | 1 | 8.66 |
| CHEMBL481537 | PK-11195 | — | 1 | 8.08 |
| CHEMBL120668 | — | — | 1 | 8.06 |
| CHEMBL121674 | — | — | 1 | 8.01 |
| CHEMBL120763 | — | — | 1 | 7.96 |
| CHEMBL331928 | — | — | 1 | 7.92 |
| CHEMBL332775 | — | — | 1 | 7.42 |
| CHEMBL325701 | — | — | 1 | 7.19 |
| CHEMBL122301 | — | — | 1 | 5.83 |
| CHEMBL119566 | — | — | 1 | 5.57 |
| CHEMBL332801 | — | — | 1 | 5.18 |
| CHEMBL120398 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325820 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL481537 | PK-11195 | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL120668 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL121674 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL120763 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL331928 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL332775 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL325701 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL122301 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL119566 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL332801 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL120398 | — | IC50 | = | 11500.0 | nM | 4.94 |