Assay Detail
Binding
CHEMBL5228430
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Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Polycomb Repressive Complex 2 Modulation through the Development of EZH2-EED Interaction Inhibitors and EED Binders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.19 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104741 | — | — | 1 | 8.82 |
| CHEMBL97453 | WEDELOLACTONE | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104741 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL97453 | WEDELOLACTONE | Kd | = | 2820.0 | nM | 5.55 |