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Assay Detail

CHEMBL5228666

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Staphylococcus aureus SrtA using EDANS-Dabcyl as substrate by FRET assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sortase A (CHEMBL5362)
Type SINGLE PROTEIN
Organism Staphylococcus aureus

Publication

Chemical Biology of Sortase A Inhibition: A Gateway to Anti-infective Therapeutic Agents.
Sapra R, Rajora AK, Kumar P, Maurya GP, Pant N, Haridas V.
J Med Chem (2021) 64 : 13097 -13130
PubMed 34516107 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.37 4.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5287601 1 4.94
CHEMBL301307 ISOAAPTAMINE 1 4.79
CHEMBL506678 SITOGLUSIDE 2.0 1 4.50
CHEMBL140 CURCUMIN 3.0 1 4.43
CHEMBL436760 BROMOTOPSENTIN 1 4.40
CHEMBL372191 DEOXYTOPSENTIN 1 4.32
CHEMBL198814 BROMODEOXYTOPSENTIN 1 4.32
CHEMBL83747 PSAMMAPLIN A 1 4.32
CHEMBL105360 1 4.15
CHEMBL5275425 1 4.14
CHEMBL5283845 1 4.08
CHEMBL284616 CHLOROGENIC ACID 2.0 1 4.02
CHEMBL105350 BISDEMETHOXYCURCUMIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5287601 IC50 = 11600.0 nM 4.94
CHEMBL301307 ISOAAPTAMINE IC50 = 16200.0 nM 4.79
CHEMBL506678 SITOGLUSIDE IC50 = 31800.0 nM 4.50
CHEMBL140 CURCUMIN IC50 = 37500.0 nM 4.43
CHEMBL436760 BROMOTOPSENTIN IC50 = 39600.0 nM 4.40
CHEMBL372191 DEOXYTOPSENTIN IC50 = 48000.0 nM 4.32
CHEMBL198814 BROMODEOXYTOPSENTIN IC50 = 47900.0 nM 4.32
CHEMBL83747 PSAMMAPLIN A IC50 = 47400.0 nM 4.32
CHEMBL105360 IC50 = 70300.0 nM 4.15
CHEMBL5275425 IC50 = 71800.0 nM 4.14
CHEMBL5283845 IC50 = 83200.0 nM 4.08
CHEMBL284616 CHLOROGENIC ACID IC50 = 95600.0 nM 4.02
CHEMBL105350 BISDEMETHOXYCURCUMIN IC50 = 103500.0 nM -