Assay Detail

CHEMBL5228679

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Binding

Inhibition of Staphylococcus aureus SrtA using FRET substrate incubated for 1 hr by FRET assay

ChEMBL ↗

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Target

Sortase A (CHEMBL5362) ↗

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Primary target Sortase A

CHEMBL5362

Anchored from Assay target.

Protein identity Sortase A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Staphylococcus aureus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sortase A (CHEMBL5362) ↗

Type	SINGLE PROTEIN
Organism	Staphylococcus aureus

Publication

Chemical Biology of Sortase A Inhibition: A Gateway to Anti-infective Therapeutic Agents.

Sapra R, Rajora AK, Kumar P, Maurya GP, Pant N, Haridas V.
J Med Chem (2021) 64 : 13097 -13130
PubMed 34516107 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.44	4.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL244743	ESCULETIN	—	1	4.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL244743	ESCULETIN	IC50	=	36160.0	nM	4.44