Assay Detail
Binding
CHEMBL5229119
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged human ALKBH3 (1 to 286 residues) using m6A-ssDNA as substrate incubated for 30 mins by MALDI-TOF-MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (CHEMBL3112376) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.10 | 4.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173876 | — | — | 1 | 4.18 |
| CHEMBL90852 | N-OXALYLGLYCINE | — | 1 | 4.01 |
| CHEMBL5274121 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173876 | — | IC50 | = | 66200.0 | nM | 4.18 |
| CHEMBL90852 | N-OXALYLGLYCINE | IC50 | = | 96800.0 | nM | 4.01 |
| CHEMBL5274121 | — | IC50 | = | 114600.0 | nM | - |