Assay Detail
Binding
CHEMBL5229121
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Inhibition of ALKBH5 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.23 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282066 | — | — | 1 | 5.91 |
| CHEMBL465179 | — | — | 1 | 5.70 |
| CHEMBL28626 | MORIN | — | 1 | 5.15 |
| CHEMBL316034 | — | — | 1 | 5.03 |
| CHEMBL418068 | RHEIN | — | 1 | 5.00 |
| CHEMBL90852 | N-OXALYLGLYCINE | — | 1 | 4.59 |
| CHEMBL302783 | — | — | 1 | - |
| CHEMBL1618358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282066 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL465179 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL28626 | MORIN | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL316034 | — | IC50 | = | 9430.0 | nM | 5.03 |
| CHEMBL418068 | RHEIN | IC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL90852 | N-OXALYLGLYCINE | IC50 | = | 25850.0 | nM | 4.59 |
| CHEMBL302783 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1618358 | — | IC50 | > | 20000.0 | nM | - |