Assay Detail
Binding
CHEMBL5229170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli AlkB-mediated demethylation using 40-mer single N3-meC containing ssDNA as substrate preincubated for 1 hr followed by substrate addition by fluorescence based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase AlkB (CHEMBL5291506) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.71 | 4.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5286796 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5286796 | — | IC50 | = | 19370.0 | nM | 4.71 |