Assay Detail
Binding
CHEMBL5229174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant ALKBH5 (unknown origin) mediated demethylase activity using methylated N6-adenine RNA probe with CUUGUCAm6ACAGCAGA sequence as substrate incubated for 2 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.92 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752151 | — | — | 1 | 6.08 |
| CHEMBL4753950 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752151 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4753950 | — | IC50 | = | 1790.0 | nM | 5.75 |