Assay Detail
Toxicity
CHEMBL5229241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Cdk2/Cyclin A using Myelin basic protein as substrate by ATP competitive assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.19 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5273566 | — | — | 1 | 6.75 |
| CHEMBL468963 | GW779439X | — | 1 | 5.85 |
| CHEMBL5316225 | — | — | 1 | 5.34 |
| CHEMBL5283441 | — | — | 1 | 5.14 |
| CHEMBL5284844 | — | — | 1 | 5.14 |
| CHEMBL5266831 | — | — | 1 | 5.03 |
| CHEMBL5277619 | — | — | 1 | 5.00 |
| CHEMBL5280561 | — | — | 1 | 4.92 |
| CHEMBL5277737 | — | — | 1 | 4.89 |
| CHEMBL5285809 | — | — | 1 | 4.62 |
| CHEMBL5266857 | — | — | 1 | 4.41 |
| CHEMBL5277580 | — | — | 1 | - |
| CHEMBL5282194 | — | — | 1 | - |
| CHEMBL5280226 | — | — | 1 | - |
| CHEMBL5283041 | — | — | 1 | - |
| CHEMBL5282708 | — | — | 1 | - |
| CHEMBL5286085 | — | — | 1 | - |
| CHEMBL5283475 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5273566 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL468963 | GW779439X | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5316225 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5283441 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5284844 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5266831 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5277619 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5280561 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5277737 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5285809 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5266857 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL5277580 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5282194 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5280226 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5283041 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5282708 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5286085 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5283475 | — | IC50 | > | 40000.0 | nM | - |