Assay Detail
Binding
CHEMBL5229264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ADAM10 expressed in baculovorus-infected Sf21 cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 1 hr followed by substrate addition and measured every 10 secs for 15 mins by fluorescence based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 10 (CHEMBL5028) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.22 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431028 | — | — | 1 | 6.82 |
| CHEMBL5283335 | — | — | 1 | 5.00 |
| CHEMBL5276957 | — | — | 1 | 4.56 |
| CHEMBL5267938 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431028 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5283335 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5276957 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL5267938 | — | IC50 | = | 30600.0 | nM | 4.51 |