Assay Detail
Binding
CHEMBL5229289
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Inhibition of ACE (unknown origin)
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pseudoprolines as stereoelectronically tunable proline isosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.08 | 8.22 |
| Ki | 1 | 8.66 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309962 | RENTIAPRIL | 2.0 | 3 | 8.66 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 2 | 7.52 |
| CHEMBL445830 | — | — | 1 | 6.43 |
| CHEMBL5272875 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309962 | RENTIAPRIL | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL309962 | RENTIAPRIL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL309962 | RENTIAPRIL | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 208.93 | nM | 6.68 |
| CHEMBL445830 | — | IC50 | = | 371.54 | nM | 6.43 |
| CHEMBL5272875 | — | IC50 | = | 831.76 | nM | 6.08 |