Assay Detail
Functional
CHEMBL5229296
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Inhibition of PAF-induced rabbit blood platelet aggregation preincubated for 2 mins followed by PAF stimulation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Platelet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pseudoprolines as stereoelectronically tunable proline isosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.64 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284792 | — | — | 1 | 7.52 |
| CHEMBL156461 | — | — | 1 | 7.15 |
| CHEMBL5277844 | — | — | 1 | 5.12 |
| CHEMBL5288474 | — | — | 1 | 4.22 |
| CHEMBL5290036 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284792 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL156461 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5277844 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL5288474 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL5290036 | — | IC50 | = | 62000.0 | nM | 4.21 |