Compound Detail
CHEMBL156461
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Basic Information
| ChEMBL ID | CHEMBL156461 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FHKSAMKFFJMXMV-BGERDNNASA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
396.6
MW (Da)
2.56
ALogP
5
HBA
1
HBD
48.5
PSA (Ų)
0.81
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL250 | IC50 | 8.64 | 8.64 | 2.3 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.15 | 7.055 | 71.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 2.3 | nM | 8.64 | Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human... | - |
| Unchecked | IC50 | = | 71.0 | nM | 7.15 | Inhibition of PAF-induced rabbit blood platelet aggregation preincubated for 2 m... | 36096342 |
| Unchecked | IC50 | = | 110.0 | nM | 6.96 | Inhibition of PAF-induced human blood platelet aggregation preincubated for 2 mi... | 36096342 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36096342 | 10.1016/j.bmcl.2022.128983 | Unchecked | 2 |
| - | 10.1016/S0960-894X(01)81205-1 | Platelet-activating factor receptor | 1 |
Data from ChEMBL 36 via Core Engine