Assay Detail
Binding
CHEMBL764537
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Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A partial pharmacophore for the platelet activating factor (PAF) receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.85 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157078 | — | — | 1 | 10.82 |
| CHEMBL156461 | — | — | 1 | 8.64 |
| CHEMBL349811 | TULOPAFANT | 2.0 | 1 | 7.96 |
| CHEMBL29067 | — | — | 1 | 7.89 |
| CHEMBL277245 | — | — | 1 | 7.40 |
| CHEMBL280164 | APAFANT | 2.0 | 1 | 7.30 |
| CHEMBL418608 | — | — | 1 | 6.52 |
| CHEMBL345902 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157078 | — | IC50 | = | 0.015 | nM | 10.82 |
| CHEMBL156461 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL349811 | TULOPAFANT | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL29067 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL277245 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL280164 | APAFANT | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL418608 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL345902 | — | IC50 | = | 500.0 | nM | 6.30 |