Compound Detail
CHEMBL277245
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Basic Information
| ChEMBL ID | CHEMBL277245 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HLCHRSFXEXAMLU-YDQNRGGDSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
1
Known Names
Molecular Properties
420.6
MW (Da)
6.14
ALogP
3
HBA
1
HBD
51.2
PSA (Ų)
0.24
QED
1
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL250 | IC50 | 7.4 | 7.4 | 40.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 40.0 | nM | 7.4 | Inhibition of [3H]PAF binding to dog platelets. | 2754709 |
| Platelet-activating factor receptor | IC50 | = | 40.0 | nM | 7.4 | Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human... | - |
| Platelet-activating factor receptor | IC50 | = | 40.0 | nM | 7.4 | PAF-antagonist activity determined in dog platelets by PAF-binding assay | 2002463 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2754709 | 10.1021/jm00128a026 | Cavia porcellus | 5 |
| 2002463 | 10.1021/jm00107a048 | Platelet-activating factor receptor | 4 |
| 2754709 | 10.1021/jm00128a026 | Platelet-activating factor receptor | 3 |
| 2754709 | 10.1021/jm00128a026 | Rattus norvegicus | 2 |
| - | 10.1016/S0960-894X(01)81205-1 | Platelet-activating factor receptor | 1 |
| 2002463 | 10.1021/jm00107a048 | Cavia porcellus | 1 |
Data from ChEMBL 36 via Core Engine