Assay Detail
Binding
CHEMBL667333
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PAF-antagonist activity determined in dog platelets by PAF-binding assay
78
Total Activities
78
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 7.65 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277701 | — | — | 1 | 9.70 |
| CHEMBL20195 | — | — | 1 | 9.52 |
| CHEMBL19640 | — | — | 1 | 9.22 |
| CHEMBL19747 | — | — | 1 | 9.15 |
| CHEMBL20019 | — | — | 1 | 9.15 |
| CHEMBL283162 | — | — | 1 | 9.00 |
| CHEMBL282883 | — | — | 1 | 9.00 |
| CHEMBL281779 | — | — | 1 | 9.00 |
| CHEMBL279665 | — | — | 1 | 8.70 |
| CHEMBL429066 | — | — | 1 | 8.52 |
| CHEMBL20163 | — | — | 1 | 8.52 |
| CHEMBL280210 | — | — | 1 | 8.40 |
| CHEMBL283339 | — | — | 1 | 8.40 |
| CHEMBL20267 | — | — | 1 | 8.40 |
| CHEMBL20418 | — | — | 1 | 8.40 |
| CHEMBL20208 | — | — | 1 | 8.30 |
| CHEMBL19947 | — | — | 1 | 8.30 |
| CHEMBL20194 | — | — | 1 | 8.30 |
| CHEMBL277029 | — | — | 1 | 8.30 |
| CHEMBL20877 | — | — | 1 | 8.30 |
| CHEMBL280683 | — | — | 1 | 8.30 |
| CHEMBL277246 | — | — | 1 | 8.22 |
| CHEMBL21224 | — | — | 1 | 8.22 |
| CHEMBL435756 | — | — | 1 | 8.22 |
| CHEMBL282905 | — | — | 1 | 8.22 |
| CHEMBL278072 | — | — | 1 | 8.15 |
| CHEMBL20003 | — | — | 1 | 8.15 |
| CHEMBL277618 | — | — | 1 | 8.15 |
| CHEMBL20323 | — | — | 1 | 8.15 |
| CHEMBL20343 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277701 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL20195 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL19640 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL19747 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL20019 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL283162 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL282883 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL281779 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL279665 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL429066 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL20163 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL20267 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL20418 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL283339 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL280210 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL20208 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL280683 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL20877 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL277029 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL20194 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL19947 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL277246 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL21224 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL435756 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL282905 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL278072 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL20323 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL20003 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL277618 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL20343 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL279234 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL19801 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL283525 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL417275 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL280401 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL277650 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL20644 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL277678 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL430333 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL418556 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL279664 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL20033 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL278635 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL20691 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL282495 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL279893 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL20293 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL277245 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL19991 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL279021 | — | IC50 | = | 50.0 | nM | 7.30 |