Compound Detail
CHEMBL20003
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1nnc2n1-c1sc(C#CCN3C(=O)C(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2
Basic Information
| ChEMBL ID | CHEMBL20003 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QALQFKFBGHKSQV-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
498.0
MW (Da)
4.22
ALogP
7
HBA
0
HBD
80.5
PSA (Ų)
0.31
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL250 | IC50 | 8.15 | 8.15 | 7.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 7.0 | nM | 8.15 | PAF-antagonist activity determined in dog platelets by PAF-binding assay | 2002463 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2002463 | 10.1021/jm00107a048 | Platelet-activating factor receptor | 2 |
| 2002463 | 10.1021/jm00107a048 | Cavia porcellus | 1 |
Data from ChEMBL 36 via Core Engine