Compound Detail
CHEMBL418608
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL418608 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MUXHEFBAOKARLM-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
397.5
MW (Da)
4.35
ALogP
4
HBA
0
HBD
55.2
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL250 | IC50 | 6.52 | 6.52 | 300.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 300.0 | nM | 6.52 | Inhibition of [3H]PAF receptor binding to washed human platelet membranes determ... | - |
| Platelet-activating factor receptor | IC50 | = | 300.0 | nM | 6.52 | Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human... | - |
| Unchecked | IC50 | = | 300.0 | nM | 6.52 | Antagonist activity at PAF (unknown origin) | 34313432 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80006-2 | Platelet-activating factor receptor | 1 |
| - | 10.1016/S0960-894X(01)81205-1 | Platelet-activating factor receptor | 1 |
| 34313432 | 10.1021/acs.jmedchem.1c00683 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine