Assay Detail
Binding
CHEMBL5229529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of OCT2(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT2 using ASP+ as substrate incubated for 5 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 2 (CHEMBL1743122) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.45 | 4.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97453 | WEDELOLACTONE | — | 1 | 4.76 |
| CHEMBL5266163 | — | — | 1 | 4.72 |
| CHEMBL28 | APIGENIN | — | 1 | 4.51 |
| CHEMBL5266270 | — | — | 1 | 4.48 |
| CHEMBL356036 | TETRAMETHYLKAEMPFEROL | — | 1 | 4.40 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.39 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 4.34 |
| CHEMBL5280198 | — | — | 1 | 4.25 |
| CHEMBL3613729 | — | — | 1 | 4.16 |
| CHEMBL4861111 | — | — | 1 | - |
| CHEMBL5285127 | — | — | 1 | - |
| CHEMBL1790041 | RANITIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97453 | WEDELOLACTONE | IC50 | = | 17330.0 | nM | 4.76 |
| CHEMBL5266163 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL28 | APIGENIN | IC50 | = | 30860.0 | nM | 4.51 |
| CHEMBL5266270 | — | IC50 | = | 33130.0 | nM | 4.48 |
| CHEMBL356036 | TETRAMETHYLKAEMPFEROL | IC50 | = | 39470.0 | nM | 4.40 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 41030.0 | nM | 4.39 |
| CHEMBL660 | AMANTADINE | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL5280198 | — | IC50 | = | 56540.0 | nM | 4.25 |
| CHEMBL3613729 | — | IC50 | = | 69480.0 | nM | 4.16 |
| CHEMBL4861111 | — | IC50 | = | 4124120.0 | nM | - |
| CHEMBL5285127 | — | IC50 | = | 1267220.0 | nM | - |
| CHEMBL1790041 | RANITIDINE | IC50 | = | 1617000.0 | nM | - |