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Assay Detail

CHEMBL5229562

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth by CCK-8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Dichapetalins from the Twigs of <i>Dichapetalum longipetalum</i> with Cytotoxic Activities.
Zhou B, Gao XH, Zhang MM, Liu HC, Yue JM.
J Nat Prod (2023) 86 : 209 -221
PubMed 36583957 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.29 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE 4.0 1 7.72
CHEMBL5281515 1 6.55
CHEMBL5279667 1 6.46
CHEMBL5290327 1 6.44
CHEMBL5270902 1 6.00
CHEMBL5280864 1 5.89
CHEMBL5273024 1 5.77
CHEMBL5285759 1 5.48
CHEMBL5277358 1 -
CHEMBL5282431 1 -
CHEMBL5278828 1 -
CHEMBL5281436 1 -
CHEMBL5282476 1 -
CHEMBL5282830 1 -
CHEMBL5288824 1 -
CHEMBL5283313 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE IC50 = 19.0 nM 7.72
CHEMBL5281515 IC50 = 280.0 nM 6.55
CHEMBL5279667 IC50 = 350.0 nM 6.46
CHEMBL5290327 IC50 = 360.0 nM 6.44
CHEMBL5270902 IC50 = 1000.0 nM 6.00
CHEMBL5280864 IC50 = 1300.0 nM 5.89
CHEMBL5273024 IC50 = 1700.0 nM 5.77
CHEMBL5285759 IC50 = 3300.0 nM 5.48
CHEMBL5277358 IC50 > 10000.0 nM -
CHEMBL5282431 IC50 > 10000.0 nM -
CHEMBL5278828 IC50 > 10000.0 nM -
CHEMBL5281436 IC50 > 10000.0 nM -
CHEMBL5282476 IC50 > 10000.0 nM -
CHEMBL5282830 IC50 > 10000.0 nM -
CHEMBL5288824 IC50 > 10000.0 nM -
CHEMBL5283313 IC50 > 10000.0 nM -