Assay Detail
Functional
CHEMBL5229577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Immunosuppressive activity in BALB/c mouse splenocytes assessed as reduction in LPS-induced mouse B-lymphocytes proliferation incubated for 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Splenocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Peniandranoids A-E: Meroterpenoids with Antiviral and Immunosuppressive Activity from a <i>Penicillium</i> sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.05 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1456 | MYCOPHENOLATE MOFETIL | 4.0 | 1 | 6.32 |
| CHEMBL5278189 | — | — | 1 | 5.12 |
| CHEMBL5286138 | — | — | 1 | 5.07 |
| CHEMBL5289661 | — | — | 1 | 5.06 |
| CHEMBL5276159 | — | — | 1 | 4.96 |
| CHEMBL5281548 | — | — | 1 | 4.92 |
| CHEMBL5279238 | — | — | 1 | 4.64 |
| CHEMBL5279809 | — | — | 1 | 4.30 |
| CHEMBL5278639 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1456 | MYCOPHENOLATE MOFETIL | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5278189 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5286138 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5289661 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5276159 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5281548 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5279238 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5279809 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5278639 | — | EC50 | > | 50000.0 | nM | - |