Assay Detail
Functional
CHEMBL5229753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 4 days by CCK-8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Transformation of Renieramycin M into Renieramycins T and S by Intramolecular Photoredox Reaction of 7-Methoxy-6-methyl-1,2,3,4-tetrahydroisoquinoline-5,8-dione Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.96 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451147 | RENIERAMYCIN M | — | 1 | 7.75 |
| CHEMBL452709 | SAFRAMYCIN A | — | 1 | 7.70 |
| CHEMBL5273157 | — | — | 1 | 7.57 |
| CHEMBL5169402 | — | — | 1 | 7.50 |
| CHEMBL5191895 | — | — | 1 | 7.09 |
| CHEMBL468488 | RENIERAMYCIN S | — | 1 | 6.80 |
| CHEMBL5285549 | — | — | 1 | 6.64 |
| CHEMBL5275238 | — | — | 1 | 5.92 |
| CHEMBL5289736 | — | — | 1 | 5.66 |
| CHEMBL5279287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451147 | RENIERAMYCIN M | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL452709 | SAFRAMYCIN A | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5273157 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5169402 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5191895 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL468488 | RENIERAMYCIN S | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5285549 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5275238 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5289736 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5279287 | — | IC50 | > | 20000.0 | nM | - |