Assay Detail
Functional
CHEMBL5229870
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Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 45 mins by gamma counter analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.14 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5274822 | — | — | 1 | 10.00 |
| CHEMBL5270513 | — | — | 1 | 9.15 |
| CHEMBL5279851 | — | — | 1 | 8.55 |
| CHEMBL5273416 | — | — | 1 | 8.48 |
| CHEMBL5282521 | — | — | 1 | 8.18 |
| CHEMBL5279511 | — | — | 1 | 8.06 |
| CHEMBL5268818 | — | — | 1 | 7.98 |
| CHEMBL5285989 | — | — | 1 | 7.58 |
| CHEMBL5266444 | — | — | 1 | 7.28 |
| CHEMBL5280483 | — | — | 1 | 7.23 |
| CHEMBL5267636 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5274822 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5270513 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5279851 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5273416 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5282521 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5279511 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5268818 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL5285989 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL5266444 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL5280483 | — | IC50 | = | 59.3 | nM | 7.23 |
| CHEMBL5267636 | — | IC50 | = | 91.8 | nM | 7.04 |