Assay Detail
Binding
CHEMBL5230438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.80 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91704 | K-777 | 2.0 | 1 | 9.17 |
| CHEMBL423112 | — | — | 1 | 8.60 |
| CHEMBL263634 | — | — | 1 | 8.16 |
| CHEMBL259450 | — | — | 1 | 7.25 |
| CHEMBL401925 | — | — | 1 | 5.27 |
| CHEMBL590799 | CAMOSTAT | 3.0 | 1 | 5.00 |
| CHEMBL5270779 | — | — | 1 | 4.12 |
| CHEMBL4790628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91704 | K-777 | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL423112 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL263634 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL259450 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL401925 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL590799 | CAMOSTAT | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5270779 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL4790628 | — | IC50 | = | - | nM | - |