Assay Detail
Functional
CHEMBL5230496
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Antiproliferative activity against mouse BaF3 FLT3-ITD cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small-Molecule Fms-like Tyrosine Kinase 3 Inhibitors: An Attractive and Efficient Method for the Treatment of Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.65 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105728 | CRENOLANIB | 3.0 | 1 | 8.89 |
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | 8.80 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 8.52 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105728 | CRENOLANIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4.14 | nM | 8.38 |