Assay Detail
Functional
CHEMBL5230512
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Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small-Molecule Fms-like Tyrosine Kinase 3 Inhibitors: An Attractive and Efficient Method for the Treatment of Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.03 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105728 | CRENOLANIB | 3.0 | 1 | 8.31 |
| CHEMBL5274495 | — | — | 1 | 8.15 |
| CHEMBL4066041 | — | — | 1 | 7.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105728 | CRENOLANIB | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5274495 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4066041 | — | IC50 | = | 23.6 | nM | 7.63 |