Assay Detail

CHEMBL5230683

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Binding

Inhibition of recombinant human Wee1 incubated for 30 mins by liquid scintillation counter method

ChEMBL ↗

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Target

Wee1-like protein kinase (CHEMBL5491) ↗

Open DB target context

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Wee1-like protein kinase (CHEMBL5491) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Wee1-like protein kinase

CHEMBL5491

Anchored from Assay target.

Protein identity Wee1-like protein kinase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Wee1-like protein kinase (CHEMBL5491) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Structure-activity relationships of Wee1 inhibitors: A review.

Du X, Li J, Luo X, Li R, Li F, Zhang Y, Shi J, He J.
Eur J Med Chem (2020) 203 : 112524 -112524
PubMed 32688199 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.29	8.29

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1976040	ADAVOSERTIB	2.0	1	8.29

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1976040	ADAVOSERTIB	IC50	=	5.1	nM	8.29