Assay Detail
Functional
CHEMBL5230960
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Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxamic acid hybrids as the potential anticancer agents: An Overview.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.04 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 2 | 6.16 |
| CHEMBL5286621 | — | — | 1 | 6.11 |
| CHEMBL5283395 | — | — | 1 | 6.11 |
| CHEMBL5281688 | — | — | 1 | 5.92 |
| CHEMBL5287361 | — | — | 1 | 5.92 |
| CHEMBL5283925 | — | — | 1 | - |
| CHEMBL5273944 | — | — | 1 | - |
| CHEMBL5270559 | — | — | 1 | - |
| CHEMBL5275537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5286621 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5283395 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5281688 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5287361 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 0.18 | ug.mL-1 | - |
| CHEMBL5283925 | — | IC50 | = | 1.28 | ug.mL-1 | - |
| CHEMBL5273944 | — | IC50 | = | 1.28 | ug.mL-1 | - |
| CHEMBL5270559 | — | IC50 | = | 1.28 | ug.mL-1 | - |
| CHEMBL5275537 | — | IC50 | = | 1.28 | ug.mL-1 | - |