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Assay Detail

CHEMBL5231297

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of SMARCA2 BD (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Probable global transcription activator SNF2L2 (CHEMBL2362979)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs).
Tomaselli D, Mautone N, Mai A, Rotili D.
Eur J Med Chem (2020) 207 : 112750 -112750
PubMed 32871345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.27 6.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4746865 1 6.43
CHEMBL5278697 1 6.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4746865 IC50 = 370.0 nM 6.43
CHEMBL5278697 IC50 = 770.0 nM 6.11