Assay Detail
Binding
CHEMBL5231310
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Inhibition of wild type Escherichia coli FabI assessed as inhibition of bacterial growth
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (CHEMBL1857) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
FabI (enoyl acyl carrier protein reductase) - A potential broad spectrum therapeutic target and its inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.87 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148515 | — | — | 1 | 9.30 |
| CHEMBL149009 | — | — | 1 | 9.15 |
| CHEMBL148755 | — | — | 1 | 8.15 |
| CHEMBL149299 | — | — | 1 | - |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148515 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL149009 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL148755 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL149299 | — | Ki | = | 0.0011 | nM | - |
| CHEMBL849 | TRICLOSAN | Ki | = | 0.007 | nM | - |