Assay Detail
Binding
CHEMBL5231345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli DH5alpha FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (CHEMBL1857) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
FabI (enoyl acyl carrier protein reductase) - A potential broad spectrum therapeutic target and its inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.07 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178284 | — | — | 1 | 7.24 |
| CHEMBL5274978 | — | — | 1 | 6.47 |
| CHEMBL5276897 | — | — | 1 | 6.40 |
| CHEMBL463175 | CEPHALOCHROMIN | — | 1 | 5.75 |
| CHEMBL5277493 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178284 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5274978 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5276897 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL463175 | CEPHALOCHROMIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5277493 | — | IC50 | = | 33200.0 | nM | 4.48 |