Assay Detail
Binding
CHEMBL5231776
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Inhibition of JAK3 (unknown origin) incubated for 45 mins by LC-MS/MS analysis
34
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An electrophilic warhead library for mapping the reactivity and accessibility of tractable cysteines in protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 24 | - | - |
| IC50 | 10 | 8.31 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5278864 | — | — | 2 | 9.11 |
| CHEMBL5270127 | — | — | 2 | 9.11 |
| CHEMBL4085582 | — | — | 2 | 9.11 |
| CHEMBL5272677 | — | — | 2 | 9.11 |
| CHEMBL5270221 | — | — | 2 | 7.25 |
| CHEMBL5287531 | — | — | 1 | 6.08 |
| CHEMBL4640448 | — | — | 1 | - |
| CHEMBL4646067 | — | — | 1 | - |
| CHEMBL5286042 | — | — | 1 | - |
| CHEMBL4647578 | — | — | 1 | - |
| CHEMBL5280633 | — | — | 1 | - |
| CHEMBL5282030 | — | — | 1 | - |
| CHEMBL5274319 | — | — | 1 | - |
| CHEMBL5271542 | — | — | 1 | - |
| CHEMBL5280200 | — | — | 1 | - |
| CHEMBL4527556 | — | — | 1 | - |
| CHEMBL5271938 | — | — | 1 | - |
| CHEMBL4639052 | — | — | 1 | - |
| CHEMBL4648216 | — | — | 1 | - |
| CHEMBL5276000 | — | — | 1 | - |
| CHEMBL4649260 | — | — | 1 | - |
| CHEMBL5269119 | — | — | 1 | - |
| CHEMBL5266284 | — | — | 1 | - |
| CHEMBL5266726 | — | — | 1 | - |
| CHEMBL4648448 | — | — | 1 | - |
| CHEMBL4638034 | — | — | 1 | - |
| CHEMBL4632641 | — | — | 1 | - |
| CHEMBL5286407 | — | — | 1 | - |
| CHEMBL4641534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085582 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL4085582 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL5272677 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL5278864 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL5270127 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL5270127 | — | IC50 | = | 1.02 | nM | 8.99 |
| CHEMBL5272677 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL5270221 | — | IC50 | = | 55.9 | nM | 7.25 |
| CHEMBL5278864 | — | IC50 | = | 55.9 | nM | 7.25 |
| CHEMBL5287531 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL5280200 | — | Inhibition | - | % | - | |
| CHEMBL4649260 | — | Inhibition | - | % | - | |
| CHEMBL5271542 | — | Inhibition | - | % | - | |
| CHEMBL5274319 | — | Inhibition | - | % | - | |
| CHEMBL5282030 | — | Inhibition | - | % | - | |
| CHEMBL4648216 | — | Inhibition | - | % | - | |
| CHEMBL4647578 | — | Inhibition | - | % | - | |
| CHEMBL5286042 | — | Inhibition | - | % | - | |
| CHEMBL4640448 | — | Inhibition | - | % | - | |
| CHEMBL4639052 | — | Inhibition | - | % | - | |
| CHEMBL4641534 | — | Inhibition | - | % | - | |
| CHEMBL5276000 | — | Inhibition | - | % | - | |
| CHEMBL4527556 | — | Inhibition | - | % | - | |
| CHEMBL5270221 | — | Inhibition | - | % | - | |
| CHEMBL5271938 | — | Inhibition | - | % | - | |
| CHEMBL4646067 | — | Inhibition | - | % | - | |
| CHEMBL5280633 | — | Inhibition | - | % | - | |
| CHEMBL5266284 | — | Inhibition | - | % | - | |
| CHEMBL5266726 | — | Inhibition | - | % | - | |
| CHEMBL4648448 | — | Inhibition | - | % | - | |
| CHEMBL4638034 | — | Inhibition | - | % | - | |
| CHEMBL4632641 | — | Inhibition | - | % | - | |
| CHEMBL5286407 | — | Inhibition | - | % | - | |
| CHEMBL5269119 | — | Inhibition | - | % | - |